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Anticholinergic Burden with Tricyclic Antidepressants: Cognitive and Cardiac Risks
Medications

Anticholinergic Burden with Tricyclic Antidepressants: Cognitive and Cardiac Risks

Tricyclic antidepressants like amitriptyline carry high anticholinergic burden, increasing risks of dementia and dangerous heart rhythms. Safer alternatives exist, and stopping them under supervision can improve cognition.

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2 December 2025 by Tristan McCarthy

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